comparison of serum autoantibodies to desmogleins i, iii in patients with oral lichen planus and healthy controls
نویسندگان
چکیده
background & objective: lichen planus is a mucocutaneous disease which is relatively common and in 30-70% of patients, mucosal lesions can be seen and known as a precancerous lesion but its etiology is not completely understood. desmogleins i and iii are the main desmosomal transmembrane proteins. these proteins have been identified as the autoantigen of the autoimmune disease. the aim of this study was evaluation of serum autoantibodies against desmogleins ι, ιιι in oral lichen planus. methods: we attempted to determine the etiology of this disease with evaluation of these serum factors. thirty-five patients with oral lichen planus and 35 healthy controls were recruited and tested for serum autoantibodies against desmogleins ι, ιιι and indirect immunofluorescence also performed. data were analyzed by statistical–analytical methods (independent sample t-test) with using the spss.15 software. results: serum autoantibody against desmoglein ι had no significant difference in the two groups (p=0.31) but significant increase in serum autoantibody to desmoglein ιιι was found in patients with oral lichen planus (p=0.00). conclusion: it seems that autoantibody against desmoglein iii has a significant role in the pathogenesis of oral lichen planus.
منابع مشابه
Comparison of Serum Autoantibodies to Desmogleins I, III in Patients with Oral Lichen Planus and Healthy Controls
Background & Objective: Lichen planus is a mucocutaneous disease which is relatively common and in 30-70% of patients, mucosal lesions can be seen and known as a precancerous lesion but its etiology is not completely understood. Desmogleins I and III are the main desmosomal transmembrane proteins. These proteins have been identified as the autoantigen of the autoimmune disease. The aim...
متن کاملComparison of Serum Autoantibodies to Desmogleins I, III in Patients with Oral Lichen Planus and Healthy Controls.
BACKGROUND & OBJECTIVE Lichen planus is a mucocutaneous disease which is relatively common and in 30-70% of patients, mucosal lesions can be seen and known as a precancerous lesion but its etiology is not completely understood. Desmogleins I and III are the main desmosomal transmembrane proteins. These proteins have been identified as the autoantigen of the autoimmune disease. The aim of this s...
متن کاملSerum autoantibodies to desmogleins 1 and 3 in patients with oral lichen planus.
AIM To determine the presence of circulating autoantibodies to desmoglein (Dsg) 1 and Dsg 3 in patients with oral lichen planus. METHODS Serum concentrations of circulating autoantibodies to Dsg 1 and Dsg 3 were determined by ELISA in 32 patients with erosive form and 25 patients with reticular form of oral lichen planus, 13 patients with acute recurrent aphthous ulcerations and 50 healthy co...
متن کاملComparison of Serum Folic Acid Level in Oral Lichen Planus Patients and Healthy Subjects
Background and aim: Oral lichen planus (OLP) is a chronic mucocutaneous inflammatory disease. Although the etiology of this disease is unknown, some factors including stress, antioxidant deficiency, and folic acid deficiency have been claimed to have a role in its incidence. The purpose of this study was to assess and compare the serum folic acid level in OLP patients and healthy subjects. Mat...
متن کاملSignificantly higher frequencies of presence of serum autoantibodies in Chinese patients with oral lichen planus.
BACKGROUND Previous studies have shown the presence of serum anti-nuclear (ANA), anti-smooth muscle (SMA), anti-mitochondrial (AMA), anti-gastric parietal cell (GPCA), anti-thyroglobulin (TGA) and anti-thyroid microsomal autoantibodies (TMA) in small groups of patients with oral lichen planus (OLP). METHODS In this study, the serum levels of ANA, SMA, AMA, GPCA, TGA and TMA were measured in a...
متن کاملSerum and salivary levels of vitamin D in oral lichen planus patients
Introduction: Vitamin D has anti-inflammatory and immunomodulatory function. The role of vitamin D deficiency has been established in the development of many types of cancers and autoimmune diseases. Oral lichen planus (OLP) is a common chronic autoimmune in oral cavity. This study aimed to evaluate the serum and salivary levels of total vitamin 25 (OH) D3 in patients with the OLP and to assess...
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عنوان ژورنال:
iranian journal of pathologyناشر: iranian society of pathology
ISSN 1735-5303
دوره 10
شماره 2 2015
کلمات کلیدی
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